ea0014p329 | (1) | ECE2007
Piehl Susanne
, Gabor Balizs
, Thomas Heberer
, Köhrle Josef
Deiodinases (5′-D1, 5′-D2, 5-D3) control the systemic and local bioavailability of thyroid hormones by removing iodine from their substrates. Thyronamine (T0AM) and 3-iodothyronamine (3-T1AM) are possible novel metabolites of classical thyroid hormones which have been demonstrated to occur endogenously and to display unique effects such as reducing body temperature in mice and activating the plasma membrane bound G-Protein coupled receptor TAAR1 (Scanlan et al.<...